The case of a geriatric female experiencing frequent falls and epileptic seizures during long-term low-dose clozapine and extended-release bupropion treatment

There are few reports describing the incidence of seizures in patients prescribed a combination clozapine and bupropion for treatment psychiatric disorders, despite known drug-drug interaction associated with concomitant use. We report case 67-year-old geriatric woman who experienced multiple falls while receiving low daily dose 200 mg extended-release (XL) 150 mg. was no recurrence seizure activity after discontinuation initiation an antiepileptic drug, divalproex. This suggests that low-dose may increase risk elderly patients.